Phenylpropanoids and polyketides
Medchemexpress LLC Neohesperidin | 13241-33-3 | 98.7% | 610.56 | 100 MG
Neohesperidin | 13241-33-3 | 98.7% | 610.56 | 100 MG
Selleck Chemical LLC Methyl-Hesperidin S2323-50mg
Methyl Hesperidin is a flavanone glycoside (flavonoid) (C28H34O15) found abundantly in citrus fruits Its aglycone form is called hesperetin
Medchemexpress LLC 5,7-dimethoxyflavone | 21392-57-4 | MFCD00016943 | 282.29 g/mol | C17H14O4 | 10 MG
5,7-Dimethoxyflavone is a flavone derivative supplied as an analytical standard for research and analytical applications. It occurs naturally in Kaempferia parviflora and is used in studies of metabolic enzyme interactions, transporter inhibition, and biological activity profiling.
- Analytical standard suitable for assay and quantification.
- Natural flavone component used in phytochemical research.
- Documented inhibitor activity against cytochrome P450 enzymes and BCRP, useful in metabolism and transporter studies.
- Supplied in small mass quantities appropriate for analytical work.
- Molecular formula C17H14O4 and molecular weight 282.29 g/mol.
Medchemexpress LLC 4H-1-benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (2S)- | 520-33-2 | MFCD00075646 | 99.12% | 302.28 | 100 MG
Hesperetin is a natural flavanone found in citrus that acts as a potent, orally active, broad-spectrum inhibitor against human UGT activity. It induces apoptosis through p38 MAPK activation and displays various bioactivities, including antioxidant, anti-inflammatory, and anti-cancer properties. Hesperetin can induce cell-cycle arrest at the G2/M phase, reduce Bcl-2, enhance BaxM, and inhibit the NF-κB receptor to induce apoptosis.
- Purity: 99.12%
- CAS no.: 520-33-2
- Appearance: solid
- Color: white to off-white
- Molecular weight: 302.28
- Formula: C16H14O6
- Structure classification: flavonoids, flavanones
- Initial source: plants other families
- Storage: powder at -20°C for 3 years, 4°C for 2 years. In solvent at -80°C for 6 months, -20°C for 1 month.
- Solubility: in DMSO, 125 mg/mL (413.52 mM).
Medchemexpress LLC Nobiletin | 478-01-3 | 99.8% | 402.39 | 1 ML
Nobiletin is a poly-methoxylated flavone derived from citrus peel, recognized for its ability to improve memory loss. It functions as a retinoid acid receptor-related orphan receptors (RORs) agonist. This compound has demonstrated potential in decreasing reactive oxygen species (ROS) levels in differentiated C2C12 myotubes, alongside exhibiting anti-inflammatory and anti-cancer properties such as anti-angiogenesis, anti-proliferation, anti-metastasis, and apoptosis induction.
- Improves memory loss
- Acts as a retinoid acid receptor-related orphan receptors (RORs) agonist
- Decreases reactive oxygen species (ROS) levels
- Possesses anti-inflammatory properties
- Exhibits anti-cancer properties (anti-angiogenesis, anti-proliferation, anti-metastasis)
- Induces apoptosis
Medchemexpress LLC AMG 487 (S-enantiomer) | 473720-30-8 | C32H28F3N5O4 | 100 MG
AMG 487 S-enantiomer is the S enantiomer of AMG 487, which acts as an antagonist of the chemokine receptor CXCR3. This chemical compound is provided as an off-white to light yellow solid with high purity.
- High purity: 99.94%
- Antagonist of chemokine receptor CXCR3
- Stable as powder at -20°C for 3 years, and 4°C for 2 years
- Stable in solvent at -80°C for 2 years, and -20°C for 1 year
- Soluble in DMSO at 100 mg/mL
Medchemexpress LLC AMG 487 (S-enantiomer) | 473720-30-8 | C32H28F3N5O4 | 1 ML
AMG 487 (S-enantiomer) is the S enantiomer of AMG 487, a potent antagonist of the chemokine receptor CXCR3. This product is intended for research use only.
- Acts as an antagonist of the chemokine receptor CXCR3
- High purity (99.94%)
- S-enantiomer form
- Suitable for research applications
Medchemexpress LLC AST 487 | 630124-46-8 | 98.9% | 529.56 | 25 MG
AST 487 is a potent RET kinase inhibitor with an IC50 of 880 nM, and also demonstrates inhibitory activity against Flt-3 with an IC50 of 520 nM. It effectively inhibits RET autophosphorylation and the activation of downstream effectors, making it suitable for studies on human thyroid cancer cell lines with activating RET mutations.
- Inhibits RET kinase (IC50 880 nM)
- Inhibits Flt-3 (IC50 520 nM)
- Targets other kinases including KDR, Flt-4, c-Kit, and c-Abl
- Potently inhibits growth of human thyroid cancer cell lines with activating RET mutations
- Functions as a novel, mutant FLT3 inhibitor
- Inhibits cellular proliferation in FLT3-ITD-Ba/F3 and D835Y-Ba/F3 cells (IC50 less than 5 nM)
Medchemexpress LLC Flavanone | 487-26-3 | 1 ML
Flavanone is a naturally occurring flavone with inhibitory activity for human estrogen synthetase (aromatase) and acts as an inhibitor for the ERK/p38/NF-κB signaling pathway. It exhibits oral activity and antitumor efficacy, demonstrating its potential in various biological processes.
- Inhibits cell proliferation, migration, and invasion of A549 cells
- Arrests cell cycle at G1 phase in vitro
- Inhibits expression of MMP-2, u-PA, cyclin D1, and CDK2
- Promotes generation of TIMP-2 and PAI-1
- Exhibits antitumor efficacy in C57BL/6J mouse models
- Limits tumor growth and inhibits metastasis of LLC cells in vivo